Selected Journal Articles:
For an up-to-date link to publications from the Fowke Lab, please click here
Retrospective Seroprevalence of Orthopoxvirus Antibodies among Key Populations, Kenya.
Loeb K, Milner KA, Lemaille C, Martens B, Stein D, Lajoie J, Shaw SY, Rimoin AW, Mbala-Kingebeni P, Hoff NA, Noyce RS, Fowke KR, Kimani J, McKinnon L, Kindrachuk J.Emerg Infect Dis. 2024 Sep;30(9):1944-1947. doi: 10.3201/eid3009.240510.
Spatial transcriptomics and in situ immune cell profiling of the host ectocervical landscape of HIV infected Kenyan sex working women.
Franzén Boger M, Kaldhusdal V, Pascual-Reguant A, Kroh S, Uecker R, Burgener AD, Lajoie J, Omollo K, Kimani J, Fowke KR, Hauser AE, Tjernlund A, Broliden K.Front Immunol. 2024 Dec 2;15:1483346. doi: 10.3389/fimmu.2024.1483346. eCollection 2024.PMID: 39687623
Sustained immune activation and impaired epithelial barrier integrity in the ectocervix of women with chronic HIV infection; Franzén Boger M, Hasselrot T, Kaldhusdal V, Miranda GHB, Czarnewski P, Edfeldt G, Bradley F, Rexaj G, Lajoie J, Omollo K, Kimani J, Fowke KR, Broliden K, Tjernlund A.PLoS Pathog. 2024 Nov 19;20(11):e1012709. doi: 10.1371/journal.ppat.1012709. eCollection 2024 Nov.
Comparative analysis of LAG3 antibodies shows differential binding patterns by flow cytometry; Graydon, Colin G., Allison Balasko, Monika Kowatsch, and Keith R. Fowke. "Comparative analysis of LAG3 antibodies shows differential binding patterns by flow cytometry." Journal of Immunological Methods 534 (2024): 113757.
Hydroxychloroquine reduces T cell activation and recall antigen responses. Kowatsch, Monika M., Julie Lajoie, Lucy Mwangi, Kenneth Omollo, Julius Oyugi, Natasha Hollett, Joshua Kimani, and Keith R. Fowke. "Hydroxychloroquine reduces T cell activation recall antigen responses." PLoS One 18, no. 8 (2023): e0287738.
Rhesus macaques show increased resistance to repeated SHIV intrarectal exposure following a heterologous regimen of rVSV vector vaccine expressing HIV antigen; Jelinski, Joseph, Monika M. Kowatsch, Marc-Alexandre Lafrance, Alice Berger, Jannie Pedersen, Hiva Azizi, Yue Li et al. "Rhesus macaques show increased resistance to repeated SHIV intrarectal exposure following a heterologous regimen of rVSV vector vaccine expressing HIV antigen." Emerging Microbes & Infections 12, no. 2 (2023): 2251595.
Low-Dose Acetylsalicylic Acid Reduces T Cell Immune Activation: Potential Implications for HIV Prevention. Lajoie J, Kowatsch MM, Mwangi LW, Boily-Larouche G, Oyugi J, Chen Y, Kimani M, Ho EA, Kimani J, Fowke KR.Front Immunol. 2021 Nov 18;12:778455. doi: 10.3389/fimmu.2021.778455. eCollection 2021.PMID: 34868050
Novel in vitro invariant natural killer T cell functional assays. Balasko A, Graydon C, Fowke KR.J Immunol Methods. 2021 Dec;499:113171. doi: 10.1016/j.jim.2021.113171. Epub 2021 Oct 24.PMID: 34706265
HIV-Exposed Seronegative Sex Workers Express Low T-Cell Activation and an Intact Ectocervical Tissue Microenvironment. Röhl M, Tjernlund A, Lajoie J, Edfeldt G, Bradley F, Bergström S, Kaldhusdal V, Åhlberg A, Månberg A, Omollo K, Boily-Larouche G, Asghar M, Kwon DS, Oyugi J, Kimani J, Nilsson P, Fowke KR, Broliden K.Vaccines (Basel). 2021 Mar 4;9(3):217. doi: 10.3390/vaccines9030217.PMID: 33806390
Differential Elevation of Inflammation and CD4+ T Cell Activation in Kenyan Female Sex Workers and Non-Sex Workers Using Depot-Medroxyprogesterone Acetate. Omollo K, Lajoie J, Oyugi J, Wessels JM, Mwaengo D, Kimani J, Kaushic C, Fowke KR.Front Immunol. 2021 Feb 23;11:598307. doi: 10.3389/fimmu.2020.598307. eCollection 2020.PMID: 33717049
LAG3's Enigmatic Mechanism of Action. Graydon CG, Mohideen S, Fowke KR.Front Immunol. 2021 Jan 8;11:615317. doi: 10.3389/fimmu.2020.615317. eCollection 2020.PMID: 33488626
Regular use of depot medroxyprogesterone acetate causes thinning of the superficial lining and apical distribution of HIV target cells in the human ectocervix. Edfeldt G, Lajoie J, Röhl M, Oyugi J, Åhlberg A, Khalilzadeh-Binicy B, Bradley F, Mack M, Kimani J, Omollo K, Wählby C, Fowke KR, Broliden K, Tjernlund A.J Infect Dis. 2020 Aug 11:jiaa514. doi: 10.1093/infdis/jiaa514.
The effects of COVID-19 on the health and socio-economic security of sex workers in Nairobi, Kenya: Emerging intersections with HIV. Kimani J, Adhiambo J, Kasiba R, Mwangi P, Were V, Mathenge J, Macharia P, Cholette F, Moore S, Shaw S, Becker M, Musyoki H, Bhattacharjee P, Moses S, Fowke KR, McKinnon LR, Lorway R.Glob Public Health. 2020 Jul;15(7):1073-1082. doi: 10.1080/17441692.2020.1770831. Epub 2020 May 27.PMID: 32459578
Retrospective Seroprevalence of Orthopoxvirus Antibodies among Key Populations, Kenya.
Loeb K, Milner KA, Lemaille C, Martens B, Stein D, Lajoie J, Shaw SY, Rimoin AW, Mbala-Kingebeni P, Hoff NA, Noyce RS, Fowke KR, Kimani J, McKinnon L, Kindrachuk J.Emerg Infect Dis. 2024 Sep;30(9):1944-1947. doi: 10.3201/eid3009.240510.
Spatial transcriptomics and in situ immune cell profiling of the host ectocervical landscape of HIV infected Kenyan sex working women.
Franzén Boger M, Kaldhusdal V, Pascual-Reguant A, Kroh S, Uecker R, Burgener AD, Lajoie J, Omollo K, Kimani J, Fowke KR, Hauser AE, Tjernlund A, Broliden K.Front Immunol. 2024 Dec 2;15:1483346. doi: 10.3389/fimmu.2024.1483346. eCollection 2024.PMID: 39687623
Sustained immune activation and impaired epithelial barrier integrity in the ectocervix of women with chronic HIV infection; Franzén Boger M, Hasselrot T, Kaldhusdal V, Miranda GHB, Czarnewski P, Edfeldt G, Bradley F, Rexaj G, Lajoie J, Omollo K, Kimani J, Fowke KR, Broliden K, Tjernlund A.PLoS Pathog. 2024 Nov 19;20(11):e1012709. doi: 10.1371/journal.ppat.1012709. eCollection 2024 Nov.
Comparative analysis of LAG3 antibodies shows differential binding patterns by flow cytometry; Graydon, Colin G., Allison Balasko, Monika Kowatsch, and Keith R. Fowke. "Comparative analysis of LAG3 antibodies shows differential binding patterns by flow cytometry." Journal of Immunological Methods 534 (2024): 113757.
Hydroxychloroquine reduces T cell activation and recall antigen responses. Kowatsch, Monika M., Julie Lajoie, Lucy Mwangi, Kenneth Omollo, Julius Oyugi, Natasha Hollett, Joshua Kimani, and Keith R. Fowke. "Hydroxychloroquine reduces T cell activation recall antigen responses." PLoS One 18, no. 8 (2023): e0287738.
Rhesus macaques show increased resistance to repeated SHIV intrarectal exposure following a heterologous regimen of rVSV vector vaccine expressing HIV antigen; Jelinski, Joseph, Monika M. Kowatsch, Marc-Alexandre Lafrance, Alice Berger, Jannie Pedersen, Hiva Azizi, Yue Li et al. "Rhesus macaques show increased resistance to repeated SHIV intrarectal exposure following a heterologous regimen of rVSV vector vaccine expressing HIV antigen." Emerging Microbes & Infections 12, no. 2 (2023): 2251595.
Low-Dose Acetylsalicylic Acid Reduces T Cell Immune Activation: Potential Implications for HIV Prevention. Lajoie J, Kowatsch MM, Mwangi LW, Boily-Larouche G, Oyugi J, Chen Y, Kimani M, Ho EA, Kimani J, Fowke KR.Front Immunol. 2021 Nov 18;12:778455. doi: 10.3389/fimmu.2021.778455. eCollection 2021.PMID: 34868050
Novel in vitro invariant natural killer T cell functional assays. Balasko A, Graydon C, Fowke KR.J Immunol Methods. 2021 Dec;499:113171. doi: 10.1016/j.jim.2021.113171. Epub 2021 Oct 24.PMID: 34706265
HIV-Exposed Seronegative Sex Workers Express Low T-Cell Activation and an Intact Ectocervical Tissue Microenvironment. Röhl M, Tjernlund A, Lajoie J, Edfeldt G, Bradley F, Bergström S, Kaldhusdal V, Åhlberg A, Månberg A, Omollo K, Boily-Larouche G, Asghar M, Kwon DS, Oyugi J, Kimani J, Nilsson P, Fowke KR, Broliden K.Vaccines (Basel). 2021 Mar 4;9(3):217. doi: 10.3390/vaccines9030217.PMID: 33806390
Differential Elevation of Inflammation and CD4+ T Cell Activation in Kenyan Female Sex Workers and Non-Sex Workers Using Depot-Medroxyprogesterone Acetate. Omollo K, Lajoie J, Oyugi J, Wessels JM, Mwaengo D, Kimani J, Kaushic C, Fowke KR.Front Immunol. 2021 Feb 23;11:598307. doi: 10.3389/fimmu.2020.598307. eCollection 2020.PMID: 33717049
LAG3's Enigmatic Mechanism of Action. Graydon CG, Mohideen S, Fowke KR.Front Immunol. 2021 Jan 8;11:615317. doi: 10.3389/fimmu.2020.615317. eCollection 2020.PMID: 33488626
Regular use of depot medroxyprogesterone acetate causes thinning of the superficial lining and apical distribution of HIV target cells in the human ectocervix. Edfeldt G, Lajoie J, Röhl M, Oyugi J, Åhlberg A, Khalilzadeh-Binicy B, Bradley F, Mack M, Kimani J, Omollo K, Wählby C, Fowke KR, Broliden K, Tjernlund A.J Infect Dis. 2020 Aug 11:jiaa514. doi: 10.1093/infdis/jiaa514.
The effects of COVID-19 on the health and socio-economic security of sex workers in Nairobi, Kenya: Emerging intersections with HIV. Kimani J, Adhiambo J, Kasiba R, Mwangi P, Were V, Mathenge J, Macharia P, Cholette F, Moore S, Shaw S, Becker M, Musyoki H, Bhattacharjee P, Moses S, Fowke KR, McKinnon LR, Lorway R.Glob Public Health. 2020 Jul;15(7):1073-1082. doi: 10.1080/17441692.2020.1770831. Epub 2020 May 27.PMID: 32459578
